A new paradigm in redox-mediated cardiac fibrosis

氧化还原介导的心脏纤维化的新范例

• 批准号: nhmrc : 1129685
• 负责人: Dr Eddy Kizana
• 金额: $ 59.22万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-paradigm-redox-cardiac-fibrosis/948439
• 关键词: new; paradigm; redox; mediated; cardiac

Fibrosis is a common feature of many forms of heart disease. Despite the recognised central role of reactive oxygen species (ROS) in cardiac fibrosis, antioxidant approaches have failed in clinical trials. We have discovered a new mechanism for ROS-mediated fibrosis that is depleted in human heart failure, and will test an innovative therapeutic approach that is imminently translatable given the development by members of our team of a specific peptide blocker effective in blocking this pathway.

纤维化是多种心脏病的共同特征。尽管公认活性氧（ROS）在心脏纤维化中的核心作用，但抗氧化方法在临床试验中失败了。我们已经发现了ros介导的纤维化在人类心力衰竭中被耗尽的新机制，并将测试一种创新的治疗方法，鉴于我们团队成员开发的一种有效阻断这一途径的特定肽阻断剂，这种治疗方法马上就可以转化。