Role of cyclin E2 in hormone-responsive breast cancer

细胞周期蛋白 E2 在激素反应性乳腺癌中的作用

• 批准号: nhmrc : 481307
• 负责人: A/Pr Jason Carroll
• 金额: $ 21.88万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cyclin-e2-breast-cancer/76141
• 关键词: Role; cyclin; E2; hormone; responsive

The female hormone estrogen stimulates the growth of breast cancers by promoting cell reproduction. We have found that cyclin E2, which is part of the machinery that controls cell reproduction, responds to estrogen. Since abnormally high levels of cyclin E2 are linked with earlier relapse in breast cancer, we wish to understand what role it plays in estrogen action and in breast cancer, how its levels are controlled, and whether too much cyclin E2 interferes with drugs that block estrogen action

女性荷尔蒙雌激素通过促进细胞繁殖来刺激乳腺癌的生长。我们已经发现，细胞周期蛋白E2是控制细胞繁殖的机制的一部分，它对雌激素有反应。由于异常高水平的细胞周期蛋白E2与乳腺癌早期复发有关，我们希望了解它在雌激素作用和乳腺癌中起什么作用，它的水平是如何被控制的，以及过多的细胞周期蛋白E2是否会干扰阻断雌激素作用的药物。