Linking breast development to bone metastasis: Role for the osteogenic transcription factor Runx2 during breast carcinogenesis

将乳房发育与骨转移联系起来：成骨转录因子 Runx2 在乳腺癌发生过程中的作用

• 批准号: nhmrc : 1012282
• 负责人: A/Pr Jason Carroll
• 金额: $ 37.68万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/linking-breast-development-breast-carcinogenesis/109646
• 关键词: Linking; breast; development; bone; metastasis

Bone is the principle metastasis site of breast cancer and represents a major cause of morbidity and mortality. Runx2 is one potential candidate gene mediating breast cancer metastasis. Using mice with altered Runx2 levels and breast cancer models, this study will examine the role of Runx2 in breast cancer bone metastasis. Identification of a single gene that controls both breast and bone would open a new area of breast cancer research and a new gene against which therapies could be developed.

骨是乳腺癌的主要转移部位，是发病率和死亡率的主要原因。Runx2是一个潜在的乳腺癌转移相关基因。使用Runx2水平改变的小鼠和乳腺癌模型，本研究将研究Runx2在乳腺癌骨转移中的作用。鉴定出一个控制乳腺和骨骼的单一基因将开辟乳腺癌研究的新领域，并开发出一种新的治疗方法。