The Role of Dendritic mRNA Decay in Synaptic Plasticity & Cognition

树突 mRNA 衰变在突触可塑性中的作用

• 批准号: nhmrc : GNT1148828
• 负责人: Mr Michael Notaras
• 金额: $ 40.88万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dendritic-mrna-plasticity-cognition/1348889
• 关键词: Role; Dendritic; mRNA; Decay; Synaptic

Schizophrenia is characterized by abnormal contacts between brain cells, known as synapses. Maintenance of synapses requires the translation of gene products, termed mRNA, into protein. Schizophrenia has been associated with genes involved in the degradation of mRNA, which buffers translation and thus protein levels. My research therefore seeks to study the role of mRNA decay in synaptic structure, synaptic function and cognition.

精神分裂症的特点是脑细胞之间的异常接触，即所谓的突触。突触的维持需要将基因产物（称为mRNA）翻译成蛋白质。精神分裂症与参与mRNA降解的基因有关，mRNA降解缓冲翻译，从而缓冲蛋白质水平。因此，我的研究旨在研究mRNA衰变在突触结构、突触功能和认知中的作用。