The role of DOCK8 in T cell polarity and function

DOCK8在T细胞极性和功能中的作用

• 批准号: nhmrc : 1079318
• 负责人: Dr Jane Oliaro
• 金额: $ 42.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dock8-t-polarity-function/518653
• 关键词: role; DOCK8; cell; polarity; function

Specialised immune cells, called cytotoxic T cells, circulate through the body, and kill infected cells to protect us from disease. We discovered that a protein, DOCK8, is important for the regulation of T cell function. Importantly, humans with mutations in the DOCK8 gene suffer from a debilitating, and potentially lethal, immunodeficiency disease. This project will therefore elucidate the role of DOCK8 in immune cells, to better understand the consequences of DOCK8 deficiency for immunity.

特殊的免疫细胞，称为细胞毒性T细胞，在体内循环，杀死被感染的细胞，以保护我们免受疾病侵袭。我们发现一种名为DOCK8的蛋白质对调节T细胞功能非常重要。重要的是，DOCK8基因突变的人类患有一种虚弱的、可能致命的免疫缺陷疾病。因此，本项目将阐明DOCK8在免疫细胞中的作用，以更好地了解DOCK8缺乏对免疫的影响。