Extracellular cues compete with TCR signalling to alter lymphocyte polarity, fate and function.

细胞外信号与 TCR 信号传导竞争，改变淋巴细胞的极性、命运和功能。

• 批准号: nhmrc : 1008908
• 负责人: Dr Jane Oliaro
• 金额: $ 34万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/extracellular-cues-compete-fate-function/109354
• 关键词: Extracellular; cues; compete; TCR; signalling

Following an infection, our immune system generates a large and diverse repertoire of cells required to mount and regulate an appropriate immune response. The signals that control the different types of immune cells that develop, and how bacteria and viruses influence immune cell development, are not fully understood. This project will investigate the regulation of immune cell development, and how competing signals from infectious agents influence this process.

感染后，我们的免疫系统产生大量和多样化的细胞库，需要安装和调节适当的免疫反应。控制不同类型免疫细胞发育的信号，以及细菌和病毒如何影响免疫细胞发育，目前还不完全清楚。这个项目将研究免疫细胞发育的调节，以及来自感染性病原体的竞争信号如何影响这一过程。