Competition for polarity influences lymphocyte differentiation and function

极性竞争影响淋巴细胞分化和功能

• 批准号: nhmrc : 509358
• 负责人: Dr Jane Oliaro
• 金额: $ 25.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/competition-polarity-influences-differentiation-function/115539
• 关键词: Competition; polarity; influences; lymphocyte; differentiation

CD46 is a protein on human cells that viruses and bacteria bind to during infection. Our laboratory has found that binding of CD46 on immune cells impairs their ability to recognize and kill target cells and may explain the immunosuppression caused by measles infection. We aim to investigate the mechanisms behind the effect of CD46 on immune cells. The outcomes of this study will define new paradigms in lymphocyte biology and determine how CD46 influences the immune response to infection.

CD46是病毒和细菌在感染过程中结合的人类细胞上的蛋白质。我们的实验室发现，免疫细胞上的CD46结合削弱了它们识别和杀死靶细胞的能力，这可能解释麻疹感染引起的免疫抑制。我们的目的是研究CD46对免疫细胞作用的机制。这项研究的结果将定义淋巴细胞生物学的新范式，并确定CD46如何影响对感染的免疫反应。