Role of the EHF transcription factor in regulating the differentiation status of colon cancers

EHF转录因子在调节结肠癌分化状态中的作用

• 批准号: nhmrc : GNT1107831
• 负责人: A/Pr Oliver Sieber
• 金额: $ 62.2万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ehf-transcription-colon-cancers/1346608
• 关键词: Role; EHF; transcription; factor; regulating

New treatment strategies for colon cancer are urgently needed. This application will test a novel approach for treating colon cancer based on the re-induction of differentiation of colon cancer cells, by reactivating a gene called EHF. We expect this to reduce the propensity for colon cancer cells to spread to distant organs and to increase their sensitivity to chemotherpay. This has the potential to significantly benefit the clinical management of patients with this disease.

结肠癌的新治疗策略是迫切需要的。该申请将测试一种新的治疗结肠癌的方法，该方法基于通过重新激活称为EHF的基因来重新诱导结肠癌细胞的分化。我们希望这能减少结肠癌细胞扩散到远处器官的倾向，并增加它们对化疗的敏感性。这有可能显着受益于这种疾病的患者的临床管理。