Population genetics and functional genomics approaches to improve outcomes for patients with colorectal cancer

群体遗传学和功能基因组学方法可改善结直肠癌患者的预后

• 批准号: nhmrc : 1062226
• 负责人: A/Pr Oliver Sieber
• 金额: $ 31.11万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/population-genetics-functional-colorectal-cancer/454968
• 关键词: Population; genetics; functional; genomics; approaches

Colorectal cancer (CRC) is the third leading cause of cancer related death in Australia, and the 5-year survival rate for metastatic disease remains below 10%. Over the next 4 years, my translational research program will focus on improving patient outcomes in four ways: Discovery of inherited variants affecting CRC risk and progression, tumour molecular classification, discovery of markers for prognosis and drug response, and elucidation of the molecular mechanisms driving CRC development.

结直肠癌（CRC）是澳大利亚癌症相关死亡的第三大原因，转移性疾病的5年生存率仍低于10%。在接下来的4年里，我的转化研究计划将专注于通过四种方式改善患者的预后：发现影响CRC风险和进展的遗传变异，肿瘤分子分类，发现预后和药物反应的标志物，以及阐明推动CRC发展的分子机制。