The role of the EphA1 in the normal epithelial organs and in epithelial tumour progression.

EphA1 在正常上皮器官和上皮肿瘤进展中的作用。

• 批准号: nhmrc : 290212
• 负责人: E/Pr Andrew Boyd
• 金额: $ 37.64万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-epha1-normal-tumour-progression/94549
• 关键词: role; EphA1; normal; epithelial; organs

The Eph family of proteins were initially found to be important in normal development. In humans this corresponds to the first 12 weeks of pregnancy. In parallel with these studies, other work provided evidence of abnormally high levels of these proteins in a number of human cancers. More recent evidence suggests that these proteins have important roles in the maintenance of normal tissues and in non-malignant diseases. This proposal seeks to understand how one of these proteins (EphA1) works in the cells which form the skin, liver, kidneys, breast and prostate. These cells also form the lining of the mouth, stomach, bowel and lungs. Understanding how the EphA1 protein and other members of this family cooperate to control the development and maintenance of these organs will allow us to determine whether this protein might be involved in congenital defects and diseases in these organs (such as kidney failure, cirrhosis of the liver and skin diseases). A second main aim of this project is to explore further the observation that Eph proteins are abnormally highly expressed in a wide rangre of human cancers. This abnormal expression is directly correlated with the tumours spreading throughout the body. EphA1 is abnormally highly expressed in cancers of the bowel, lung, breast and prostate. These are the commonest cancers in man and some of the most difficult to treat. The work proposed asks how EphA1 contributes to the development and progression of these cancers. These results will have very direct implications for the development of therapies which target the EphA1 protein.

Eph蛋白家族最初被发现在正常发育中很重要。在人类中，这相当于怀孕的前12周。与这些研究平行的是，其他工作提供了这些蛋白质在许多人类癌症中异常高水平的证据。最近的证据表明，这些蛋白质在维持正常组织和非恶性疾病中具有重要作用。该提案旨在了解其中一种蛋白质（EphA 1）如何在形成皮肤、肝脏、肾脏、乳腺和前列腺的细胞中发挥作用。这些细胞还形成口腔、胃、肠和肺的内壁。了解EphA1蛋白和这个家族的其他成员如何合作来控制这些器官的发育和维持，将使我们能够确定这种蛋白是否可能参与这些器官的先天性缺陷和疾病（如肾衰竭，肝硬化和皮肤病）。该项目的第二个主要目的是进一步探索Eph蛋白在广泛的人类癌症中异常高表达的观察结果。这种异常表达与肿瘤扩散到全身直接相关。EphA1在肠癌、肺癌、乳腺癌和前列腺癌中异常高表达。这些是人类最常见的癌症，也是最难治疗的癌症之一。这项工作提出了EphA1如何促进这些癌症的发展和进展。这些结果将对靶向EphA1蛋白的疗法的开发具有非常直接的意义。