Therapeutic development of a novel EphA4 antagonist for spinal cord injuries

脊髓损伤给患者及其照顾者带来了沉重的负担。目前，还没有治疗脊髓损伤的方法可以提供功能改善。这项研究计划将开发一种新的治疗分子EphA4-Fc，它可以促进轴突再生，并提供显著的功能改善。我们将确定最有效的EphA4-FC给药方案以及这些治疗方案的生理和功能结果。

Spinal cord injuries impose a significant burden on patients and their carers. At present, there are no treatments for spinal cord injury that provide functional improvement. This research program will develop a novel therapeutic molecule, EphA4-Fc, which promotes axonal regeneration and delivers significant functional improvement. We will determine the most effective protocol for EphA4-Fc administration and the physiological and functional outcomes of these treatment regimes.