The Role of Eph-ephrin Interactions in Mediating Mesenchymal Stem Cell Commitment, Migration and Bone Fracture Repair

肝配蛋白相互作用在介导间充质干细胞定向、迁移和骨折修复中的作用

• 批准号: nhmrc : 565176
• 负责人: A/Pr Koichi Matsuo
• 金额: $ 38.62万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-eph-ephrin-fracture-repair/95713
• 关键词: Role; Eph; ephrin; Interactions; Mediating

In Australia, there is an increasing incidence of fractures that require surgical intervention and rehabilitation therapy. Fracture healing is a complex process that involves the coordination of different bone and immune cells. Our proposal will identify which cell-cell contact molecules mediate bone cell recruitment and development during normal skeletal growth and bone fracture repair. This study will help advance therapies for fracture repair and diseases of bone loss.

在澳大利亚，骨折的发生率越来越高，需要手术干预和康复治疗。骨折愈合是一个复杂的过程，涉及不同骨细胞和免疫细胞的协调。我们的建议将确定在正常骨骼生长和骨折修复过程中，哪些细胞-细胞接触分子介导骨细胞募集和发育。这项研究将有助于促进骨折修复和骨质流失疾病的治疗。