ROLE OF EPHRIN-EPH SIGNALLING IN THE FORMATION PHASE OF BONE REMODELLING

Ephrin-EPH 信号传导在骨重塑形成阶段的作用

• 批准号: nhmrc : 620200
• 负责人: A/Pr Natalie Sims
• 金额: $ 35.9万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ephrin-eph-bone-remodelling/82128
• 关键词: ROLE; EPHRIN; EPH; SIGNALLING; FORMATION

Bone is constantly being renewed through bone remodelling. An amount of bone is removed by osteoclasts, and bone-forming osteoblasts make just enough to fill the space. We discovered that proteins known as ephrins are produced by osteoblasts, and act on neighbouring osteoblasts to help them make new bone. We aim to define how ephrins increase bone formation in remodelling, how that is controlled and how it might be used to find ways to increase bone formation.

骨骼通过骨骼重塑不断更新。破骨细胞会去除一定量的骨头，而形成骨的成骨细胞则刚好足以填充空间。我们发现，称为肝配蛋白的蛋白质是由成骨细胞产生的，并作用于邻近的成骨细胞，帮助它们制造新骨。我们的目标是确定肝配蛋白如何在重塑过程中增加骨形成，如何控制它以及如何使用它来寻找增加骨形成的方法。