The Role of Eph/ephrin clustering and trafficking in control of tumour cell invasion

Eph/ephrin 聚集和运输在控制肿瘤细胞侵袭中的作用

• 批准号: nhmrc : 334085
• 负责人: A/Pr Martin Lackmann
• 金额: $ 29.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ephephrin-clustering-cell-invasion/78086
• 关键词: Role; Eph; ephrin; clustering; trafficking

Eph and ephrin proteins are important for normal development of the embryo by controlling cell positioning. In adult tissues these proteins are present at low levels but are found at high levels in human cancers, including skin cancers, where their presence is thought to promote aggressive tumours. We wish to understand how these proteins control cell movement and contribute to cancer progression so that we can develop new cancer therapies.

Eph和ephrin蛋白通过控制细胞定位对胚胎的正常发育起重要作用。在成人组织中，这些蛋白质的含量很低，但在包括皮肤癌在内的人类癌症中含量很高，人们认为它们的存在会促进侵袭性肿瘤的发生。我们希望了解这些蛋白质如何控制细胞运动并促进癌症进展，以便我们能够开发新的癌症治疗方法。