The role of exosome-like vesicles in cell-cell communication between P. falciparum-infected red blood cells

外泌体样囊泡在恶性疟原虫感染的红细胞之间细胞通讯中的作用

• 批准号: nhmrc : 1057960
• 负责人: Dr Danny Wilson
• 金额: $ 41.95万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-exosome-like-blood-cells/454646
• 关键词: role; exosome; like; vesicles; cell

Cell-cell communication is a critically important mechanism for information exchange promoting cell survival by control of features such as population density and differentiation state. Malaria is caused by the parasite Plasmodium falciparum. We have shown that P. falciparum-infected red blood cells directly communicate between parasites within a population using small vesicles that are capable of delivering genes and signals. Our work aims to understand this process.

细胞间通讯是一种重要的信息交换机制，通过控制细胞群密度和分化状态等特征来促进细胞存活。疟疾是由恶性疟原虫引起的。我们已经证明，感染恶性疟原虫的红细胞使用能够传递基因和信号的小泡囊在种群内的寄生虫之间直接交流。我们的工作旨在了解这一过程。