The role of phosphorylation and signalling for invasion of Plasmodium falciparum into human erythrocytes.

磷酸化和信号传导在恶性疟原虫侵入人红细胞中的作用。

• 批准号: nhmrc : 1035715
• 负责人: Dr Danny Wilson
• 金额: $ 20.53万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-phosphorylation-signalling-human-erythrocytes/110977
• 关键词: role; phosphorylation; signalling; invasion; Plasmodium

The intracellular signals that govern Plasmodium falciparum malaria invasion of the red blood cell are poorly understood. It is likely calcium dependent phosphorylation leads to recruitment and activation of a cascade of proteins. This study combines a break-through in purification of viable P. falciparum merozoites with proteomic analysis of phosphorylation states to assess intracellular signalling. It is expected the processes identified will be unique to P. falciparum and targetable by drugs.

控制恶性疟原虫疟疾侵入红细胞的细胞内信号知之甚少。钙依赖性磷酸化可能导致蛋白质级联的募集和激活。这项研究结合了一个突破性的纯化活恶性疟原虫裂殖子的磷酸化状态的蛋白质组学分析，以评估细胞内信号。预计所确定的过程将是恶性疟原虫独有的，并可被药物靶向。