An i nvest i gat i on i nto the cause of and i tory ha I I uc i nat i on and and i tory information processing deficits in schizophrenia

对精神分裂症的幻觉和记忆信息处理缺陷的原因和记忆信息处理缺陷的调查

• 批准号: 22791129
• 负责人: HIRANO Yoji
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791129/
• 关键词: 統合失調症; 幻聴; Auditory information processing; Audio-Visual integration; 脳磁図; 脳波; 時間周波数解析; 聴覚情報処理; 聴覚-視覚情報統合; 聴覚情報処理機構; 誘発磁場

The aim of this study was to investigate the neural basis of auditory hallucination in schizophrenia. We analyzed the neural activities related to auditory hallucinations or the audio-visual integration process using new neurophysiological methods. We found that abnormalγ-band neural oscillation activities evoked during audio, visual and audio-visual integration were prominently involved in the neural basis of auditory hallucinations in schizophrenia. These results may contribute to the development of diagnoses, therapies and provide clues to the underlying cause of schizophrenia.

本研究旨在探讨精神分裂症幻听的神经基础。我们用新的神经生理学方法分析了与幻听或视听整合过程有关的神经活动。我们发现，在听、视、视听整合过程中诱发的异常γ-带神经振荡活动显著参与了精神分裂症幻听的神经基础。这些结果可能有助于诊断和治疗的发展，并为精神分裂症的潜在原因提供线索。

项目成果

Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia

• DOI: 10.1016/j.schres.2011.07.020
• 发表时间: 2011-12
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: R. Tsuchimoto;S. Kanba;S. Hirano;N. Oribe;T. Ueno;Y. Hirano;I. Nakamura;Y. Oda;T. Miura;T. Onitsuka

Stability of the Rayleigh distribution

瑞利分布的稳定性

• 发表时间: 2011
• 期刊: Proc International Cong Imaging Signal Processing IEEE
• 作者: Ueno T;Hirano S;Hirano Y;Oribe N;Nakamura I;Oda Y;Kanba S;Onitsuka T
• 通讯作者: Onitsuka T

Audio-visual multimodal integration activity in human brain : An MEG study

人脑视听多模态整合活动：脑磁图研究

• 发表时间: 2011
• 作者: Nakamura I and Hirano Y;Ohara N;Oribe N;Hirano S;Ueno T;Onitsuka T
• 通讯作者: Onitsuka T

Auditory gating deficit to human voices in schizophrenia: A MEG study

• DOI: 10.1016/j.schres.2009.09.003
• 发表时间: 2010-03-01
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Hirano, Yoji;Hirano, Shogo;Onitsuka, Toshiaki
• 通讯作者: Onitsuka, Toshiaki

Functional and Structural Evidence

功能和结构证据

• 发表时间: 2012
• 作者: Hirano Y;Quan M;Niznikiewicz M;McCarley RW;Spencer KM : Abnormalγ-band Auditory Steady-State Responses in Schizophrenia
• 通讯作者: Spencer KM : Abnormalγ-band Auditory Steady-State Responses in Schizophrenia