The role of the glutamine transporter SNAT3 in ion transport, cell signaling and ammonia detoxification

谷氨酰胺转运蛋白 SNAT3 在离子转运、细胞信号传导和氨解毒中的作用

• 批准号: nhmrc : 585479
• 负责人: Dr Megan O'Mara
• 金额: $ 26.22万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-glutamine-transporter-ammonia-detoxification/83183
• 关键词: role; glutamine; transporter; SNAT3; ion

Hepatic encephalopathy is a syndrome observed in patients with liver cirrhosis and is caused by increased amounts of ammonia in the blood. The proposed project investigates a transporter that is involved in ammonia and glutamine metabolism in liver and brain. The two organs are critical to the pathology of liver failure and ammonia toxicity resulting from reduced liver function. The transporter thus could become a drug target for a variety of liver diseases.

肝性脑病是肝硬化患者中观察到的一种综合征，由血液中氨含量增加引起。该项目研究了一种参与肝脏和大脑中氨和谷氨酰胺代谢的转运蛋白。这两个器官对于肝功能衰竭和肝功能下降导致的氨中毒的病理学至关重要。因此，转运蛋白可能成为多种肝脏疾病的药物靶点。