The role of glycaemic variability in influenza virus pathogenesis and immunity

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People with diabetes are at risk of severe flu infections. However, the mechanisms that drive this susceptibility are incompletely understood. This project will investigate whether variable blood sugar levels in patients with diabetes increase the severity of the flu and impair the immune response by causing oxidative stress. In doing so, this project aims to identify if reducing oxidative stress will reduce the severity of the flu in patients with diabetes.