The role of Grb10 in the regulation of muscle metabolism

肥胖会增加患代谢性疾病的风险，比如2型糖尿病。肌肉是平衡能量是被使用还是被储存为脂肪的关键组织，随着年龄的增长，肌肉质量通常会减少，这使得保持健康的新陈代谢变得更加困难。我们已经发现，从老鼠身上去除Grb10基因可以产生更大的肌肉。该项目将研究这种影响的机制，以便制定策略来调节肌肉质量和改善代谢健康

Obesity increases the risk of metabolic diseases such as type 2 diabetes. Muscle is a key tissue for balancing whether energy is used or stored as fat and as we age, muscle mass normally decreases making maintaining a healthy metabolism even more difficult. We have discovered that removing the Grb10 gene from mice produces bigger muscles. This project will investigate the mechanisms of this effect so that strategies can be developed to regulate muscle mass and improve metabolic health