The role of Grb10 in the regulation of muscle metabolism

Grb10在肌肉代谢调节中的作用

• 批准号: nhmrc : 1009794
• 负责人: Dr Lowenna Holt
• 金额: $ 41.67万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-grb10-regulation-muscle-metabolism/109428
• 关键词: role; Grb10; regulation; muscle; metabolism

Obesity increases the risk of metabolic diseases such as type 2 diabetes. Muscle is a key tissue for balancing whether energy is used or stored as fat and as we age, muscle mass normally decreases making maintaining a healthy metabolism even more difficult. We have discovered that removing the Grb10 gene from mice produces bigger muscles. This project will investigate the mechanisms of this effect so that strategies can be developed to regulate muscle mass and improve metabolic health

肥胖会增加患2型糖尿病等代谢性疾病的风险。肌肉是平衡能量的关键组织，无论能量是被使用还是以脂肪的形式储存，随着我们年龄的增长，肌肉质量通常会减少，这使得维持健康的新陈代谢变得更加困难。我们已经发现，从老鼠身上移除Grb10基因会产生更大的肌肉。该项目将研究这种影响的机制，以便制定出调节肌肉质量和改善代谢健康的策略。