The role of HIV infection of astrocytes in the development of HIV associated dementia

HIV感染星形胶质细胞在HIV相关痴呆发展中的作用

• 批准号: nhmrc : 281215
• 负责人: Prof Bruce Brew
• 金额: $ 9.62万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hiv-infection-associated-dementia/94512
• 关键词: role; HIV; infection; astrocytes; development

Dementia is an extremely common problem in the late stages of Human Immunodeficiency Virus (HIV) infection. HIV-associated dementia is the most common cause of dementia in people under 40 years of age. Despite the development of very good drugs to attack the virus, HIV-associaed dementia continues to be a major clinical problem. We are looking at the reasons why some people infected with HIV become demented and others do not. We are also looking at how best to prevent the development of dementia. We believe that astrocytes (an important brain cell that supports neurons) play a very important role in the development of HIV-associated dementia. With an improved understanding of the steps leading to dementia we can better plan treatments to prevent the development of this devastating complication of HIV-AIDS.

痴呆症是人类免疫缺陷病毒（HIV）感染晚期极为常见的问题。艾滋病毒相关的痴呆症是40岁以下人群中痴呆症的最常见原因。尽管开发了非常好的药物来攻击这种病毒，但艾滋病毒相关的痴呆仍然是一个主要的临床问题。我们正在研究为什么一些感染了艾滋病毒的人会变得精神错乱，而另一些人却不会。我们也在研究如何最好地预防痴呆症的发展。我们认为星形胶质细胞（一种支持神经元的重要脑细胞）在hiv相关痴呆的发展中起着非常重要的作用。随着对导致痴呆症的步骤的进一步了解，我们可以更好地制定治疗计划，以防止这种毁灭性的艾滋病并发症的发展。