The role of IL-17 in regulating liver macrophage permissiveness for Leishmania infection

IL-17在调节肝巨噬细胞允许利什曼原虫感染中的作用

• 批准号: nhmrc : 1105817
• 负责人: Dr Geoffrey Gobert
• 金额: $ 44.91万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-il-17-leishmania-infection/662862
• 关键词: role; IL; 17; regulating; liver

Visceral Leishmaniasis is a disease of poverty in the developing world caused by Leishmania parasites, which live and replicate within host tissue macrophages. A cytokine produced by host cells, IL-17A impairs the ability of liver macrophages to control this infection, as mice that lack IL-17A have lower parasite burdens in the liver after experimental infection. We propose to investigate if IL-17A mediates this impaired control by tuning the permissiveness of host macrophages to infection.

内脏利什曼病是发展中国家的一种贫困疾病，由利什曼原虫寄生虫引起，寄生虫在宿主组织巨噬细胞内生存和复制。由宿主细胞产生的细胞因子IL-17 A损害肝脏巨噬细胞控制这种感染的能力，因为缺乏IL-17 A的小鼠在实验感染后肝脏中的寄生虫负荷较低。我们建议调查，如果IL-17 A介导这种受损的控制调节宿主巨噬细胞感染的许可。