Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy
Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy
靶向血吸虫钙信号传导以提高和扩大吡喹酮功效
批准号：
nhmrc : 1080007
负责人：
Dr Geoffrey Gobert
金额：
$32.12万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
Schistosomiasis is caused by parasitic worms, treatment relies solely on praziquantel (PZQ). Schistosomes respond and recover from PZQ exposure through modulation of the gene CamKII. We will target this gene to both increase and extend the efficacy of PZQ in both adult parasites and in refractory juvenile parasites. Research will expand into assaying CamKII inhibitors to maximise effectiveness and take this work into animal models of this disease.
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会议论文
The role of IL-17 in regulating liver macrophage permissiveness for Leishmania infection
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批准号：nhmrc : 1105817
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项目类别：Project Grants
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资助金额：$44.91万
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财政年份：2016
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负责人：Dr Geoffrey Gobert
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依托单位：
The role of IL-17 in regulating liver macrophage permissiveness for Leishmania infection
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批准号：nhmrc : GNT1105817
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项目类别：Project Grants
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资助金额：$65.51万
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财政年份：2016
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负责人：Dr Geoffrey Gobert
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依托单位：
Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy
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批准号：nhmrc : GNT1080007
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项目类别：Project Grants
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资助金额：$46.65万
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财政年份：2015
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负责人：Dr Geoffrey Gobert
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依托单位：
Transcriptome Profiling of the Human Pathogen Schistosoma japonicum
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批准号：nhmrc : 442927
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项目类别：NHMRC Project Grants
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资助金额：$17.17万
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财政年份：2007
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负责人：Dr Geoffrey Gobert
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依托单位：
Integration of microarray and transgenics technologies in the study of Schistoma
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批准号：nhmrc : 339469
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项目类别：NHMRC Postgraduate Scholarships
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资助金额：$0.57万
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财政年份：2005
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负责人：Dr Geoffrey Gobert
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依托单位：
Characterisation of secretory and surface proteins in human schistomes identified by signal sequence trap
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批准号：nhmrc : 199635
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项目类别：Early Career Fellowships
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资助金额：$13.69万
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财政年份：2003
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负责人：Dr Geoffrey Gobert
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依托单位：
海外基金
