Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy

靶向血吸虫钙信号传导以提高和扩大吡喹酮功效

• 批准号: nhmrc : 1080007
• 负责人: Dr Geoffrey Gobert
• 金额: $ 32.12万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-schistosome-calcium-praziquantel-efficacy/518717
• 关键词: Targeting; Schistosome; Calcium; Signalling; Improve

Schistosomiasis is caused by parasitic worms, treatment relies solely on praziquantel (PZQ). Schistosomes respond and recover from PZQ exposure through modulation of the gene CamKII. We will target this gene to both increase and extend the efficacy of PZQ in both adult parasites and in refractory juvenile parasites. Research will expand into assaying CamKII inhibitors to maximise effectiveness and take this work into animal models of this disease.

血吸虫病是由寄生虫引起的，仅靠吡喹酮(PZQ)治疗。血吸虫通过调节CaMKII基因对PZQ暴露后的反应和恢复。我们将以该基因为靶点，增加和扩大PZQ在成虫和难治性幼虫中的疗效。研究将扩展到测试CaMKII抑制剂，以最大化效果，并将这项工作应用于这种疾病的动物模型。