Role of IL-3 in allergic inflammation: modulation of basophils, mast cells, eosinophils and remodelling in asthma.

IL-3 在过敏性炎症中的作用：调节嗜碱性粒细胞、肥大细胞、嗜酸性粒细胞和哮喘重塑。

• 批准号: nhmrc : 471481
• 负责人: Prof Ian Young
• 金额: $ 33.03万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-il-3-remodelling-asthma/97227
• 关键词: Role; IL; allergic; inflammation; modulation

Asthma is an important disease in the Australian community. We will investigate how the underlying inflammation in this disease is controlled and will focus our studies on a hormone-like regulator of the immune system called interleukin-3. Our hypothesis is that interleukin-3 regulates basophils, mast cells and remodelling of the airways which are central features of asthma. This study will give a better understanding of how the inflammation is caused and information for new drug targets.

哮喘是澳大利亚社区的一种重要疾病。我们将研究这种疾病的潜在炎症是如何控制的，并将我们的研究集中在一种称为白细胞介素-3的免疫系统的类似免疫调节剂上。我们的假设是，白细胞介素-3调节嗜碱性粒细胞，肥大细胞和气道重塑，这是哮喘的中心特征。这项研究将更好地了解炎症是如何引起的，并提供新药物靶点的信息。