Role of IL-3 in allergic inflammation: modulation of basophils, mast cells, eosinophils and remodelling in asthma.

哮喘是澳大利亚社会的一种重要疾病。我们将研究这种疾病的潜在炎症是如何被控制的，并将我们的研究重点放在免疫系统的激素样调节剂白介素-3上。我们的假设是，白细胞介素-3调节嗜碱性细胞、肥大细胞和气道重塑，这是哮喘的主要特征。这项研究将更好地了解炎症是如何引起的，并为新的药物靶点提供信息。

Asthma is an important disease in the Australian community. We will investigate how the underlying inflammation in this disease is controlled and will focus our studies on a hormone-like regulator of the immune system called interleukin-3. Our hypothesis is that interleukin-3 regulates basophils, mast cells and remodelling of the airways which are central features of asthma. This study will give a better understanding of how the inflammation is caused and information for new drug targets.