Targeting miRNA to inhibit leukocyte differentiation: a novel anti-inflammatory approach for the treatment of asthma

靶向 miRNA 抑制白细胞分化：治疗哮喘的新型抗炎方法

• 批准号: nhmrc : 1026410
• 负责人: Prof Ian Young
• 金额: $ 40.1万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-mirna-inhibit-treatment-asthma/110493
• 关键词: Targeting; miRNA; inhibit; leukocyte; differentiation

In asthma, the symptoms are caused by an allergic reaction in the lung and the production of inflammatory cells whose maturation is guided by tiny molecules called “microRNAs”. The critical microRNAs will be identified and strategies to block their function developed and tested for their ability to inhibit allergic inflammation to evaluate this approach as a new treatment for asthma.

在哮喘中，症状是由肺中的过敏反应和炎症细胞的产生引起的，这些炎症细胞的成熟由称为“microRNA”的小分子指导。将确定关键的microRNA，并开发阻断其功能的策略，并测试其抑制过敏性炎症的能力，以评估这种方法作为哮喘的新治疗方法。