Role of L1CAM in enteric nervous system development

L1CAM 在肠神经系统发育中的作用

• 批准号: nhmrc : 509219
• 负责人: Dr Richard Anderson
• 金额: $ 24.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-l1cam-enteric-nervous-development/98123
• 关键词: Role; L1CAM; enteric; nervous; system

There are millions of nerve cells in the gut. During development, these nerve cells arise from cells (neural crest) that migrate from the developing brain. Neural crest cells migrate into and along the gut. Some humans have a condition called Hirschsprung's disease in which nerve cells are absent from parts of the gut. Afflicted individuals have severe constipation and require surgery. In this study, we will identify the mechanisms controlling neural crest migration in the developing gut.

肠道中有数百万个神经细胞。在发育过程中，这些神经细胞来自从发育中的大脑迁移的细胞（神经嵴）。神经嵴细胞迁移进入肠道并沿着肠道。有些人患有先天性巨结肠症，部分肠道缺乏神经细胞。患者有严重的便秘，需要手术治疗。在这项研究中，我们将确定机制控制神经嵴迁移在发展肠道。