Guidance molecules involved in the development of the enteric nervous system

参与肠神经系统发育的引导分子

• 批准号: nhmrc : 350311
• 负责人: Dr Richard Anderson
• 金额: $ 24.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/guidance-molecules-involved-enteric-nervous/96062
• 关键词: Guidance; molecules; involved; development; enteric

There are millions of nerve cells within the wall of the intestine, and they control many intestinal functions, including motility. During development, these nerve cells arise from cells which migrate away from the developing brain and first enter the stomach. The migratory cells are called 'neural crest' cells. After entering the stomach, neural crest cells migrate within the wall of the gastrointestinal tract, until they reach the far (anal) end. In embryonic mice, this colonisation of the entire gut by neural crest cells takes over four days, and in humans the process probably takes around three weeks. It is essential that neural crest cells colonise the entire gastrointestinal tract, since regions of intestine lacking neural crest cells (and hence nerve cells) cannot function and intestinal contents build up in front of the region lacking nerve cells. This condition is found in some babies (Hirschsprung's disease), and it can only be treated by surgically removing the region lacking nerve cells. Currently, little is known about the mechanisms controlling the migration of neural crest cells within the gut, and whether particular molecules are involved in this process. In this study, we will use a variety of methods to identify the molecules that are involved in the migration of neural crest cells into and along the developing gut.

肠壁内有数百万个神经细胞，它们控制着许多肠道功能，包括运动。在发育过程中，这些神经细胞从发育中的大脑中迁移出来，首先进入胃。这些迁移细胞被称为“神经脊”细胞。进入胃后，神经脊细胞在胃肠道壁内迁移，直到它们到达远(肛门)端。在胚胎小鼠中，神经脊细胞对整个肠道的定植需要四天以上，而在人类中，这个过程可能需要大约三周的时间。神经脊细胞定植于整个胃肠道是至关重要的，因为肠道中缺乏神经脊细胞的区域(因此神经细胞)不能发挥作用，肠道内容物在缺乏神经细胞的区域前面堆积。这种情况在一些婴儿身上发现(先天性巨结肠症)，只能通过手术切除缺乏神经细胞的区域来治疗。目前，人们对肠道内神经脊细胞迁移的控制机制以及特定分子是否参与这一过程知之甚少。在这项研究中，我们将使用各种方法来确定与神经脊细胞迁移到发育中的肠道并沿着发育的肠道迁移有关的分子。