Role of the LIM-only protein LMO4 in lung development and lung cancer

仅 LIM 蛋白 LMO4 在肺发育和肺癌中的作用

• 批准号: nhmrc : 1045810
• 负责人: Dr Marie-Liesse Asselin-Labat
• 金额: $ 32.7万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-lim-only-lung-cancer/111790
• 关键词: Role; LIM; only; protein; LMO4

Lung cancer is the leading cause of death in cancer patients in Australia. Although treatments have improved in the past 10 years, new therapeutic strategies are eagerly awaited. Deregulation of molecules driving development of normal tissue is often observed in cancer. Our aim is to identify key regulators of lung development and lung repair after injury. We aim to evaluate the role of these molecules in the initiation and progression of lung cancer to identify new targets for therapies.

肺癌是澳大利亚癌症患者死亡的主要原因。虽然治疗方法在过去10年中有所改善，但人们仍热切期待新的治疗策略。在癌症中经常观察到驱动正常组织发育的分子失调。我们的目的是确定肺发育和损伤后肺修复的关键调节因子。我们的目标是评估这些分子在肺癌的发生和发展中的作用，以确定新的治疗靶点。