Regulation of lung stem cells in development and disease

肺干细胞在发育和疾病中的调节

• 批准号: nhmrc : 1106531
• 负责人: Dr Marie-Liesse Asselin-Labat
• 金额: $ 31.35万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-lung-stem-development-disease/662916
• 关键词: Regulation; lung; stem; cells; development

Breathing air at birth depends on the generation of normal lung structures. Using multiple approaches, we aim to identify factors that control embryonic lung development and adult lung remodeling by stem cells. This will define the molecular events that are critical in normal lung formation that may be altered in lung disorders such as respiratory distress syndrome of prematurity, and will have a significant impact on the future management of lung diseases.

出生时呼吸空气取决于正常肺结构的生成。使用多种方法，我们的目标是确定控制胚胎肺发育和成人肺重塑干细胞的因素。这将定义在肺疾病（如早产儿呼吸窘迫综合征）中可能发生改变的正常肺形成中至关重要的分子事件，并将对未来肺部疾病的管理产生重大影响。