Role of the microRNA target Quaking in alternative splicing during cancer progression

microRNA 靶标 Quaking 在癌症进展过程中选择性剪接中的作用

• 批准号: nhmrc : GNT1068773
• 负责人: Dr Philip Gregory
• 金额: $ 28.59万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-microrna-target-cancer-progression/1344955
• 关键词: Role; microRNA; target; Quaking; alternative

The spread of cancer to other organs involves cancer cells changing to a more aggressive state and is a major cause of cancer related death. MicroRNAs are a class of genes that control whether cancer cells become more aggressive by regulating other genes. In this project we will examine the function of a new microRNA target which controls the cancer cell aggression. The outcome will be a better understanding of how cancers spread and the identification of new therapeutic targets.

癌症扩散到其他器官涉及癌细胞转变为更具侵袭性的状态，是癌症相关死亡的主要原因。MicroRNAs是一类基因，通过调节其他基因来控制癌细胞是否变得更具侵袭性。在这个项目中，我们将研究一种控制癌细胞侵袭的新的microRNA靶标的功能。其结果将是更好地了解癌症是如何扩散的，并确定新的治疗靶点。