Role of the miR-200 target Quaking in alternative splicing during EMT and cancer progression

癌症扩散到其他器官涉及癌细胞转变为更具侵袭性的状态，是癌症相关死亡的主要原因。MicroRNAs是一类基因，通过调节其他基因来控制癌细胞是否变得更具侵袭性。在这个项目中，我们将研究一种控制癌细胞侵袭的新的microRNA靶标的功能。其结果将是更好地了解癌症是如何扩散的，并确定新的治疗靶点。

The spread of cancer to other organs involves cancer cells changing to a more aggressive state and is a major cause of cancer related death. MicroRNAs are a class of genes that control whether cancer cells become more aggressive by regulating other genes. In this project we will examine the function of a new microRNA target which controls the cancer cell aggression. The outcome will be a better understanding of how cancers spread and the identification of new therapeutic targets.