Role of the miR-200 target Quaking in alternative splicing during EMT and cancer progression

miR-200 靶标 Quaking 在 EMT 和癌症进展过程中选择性剪接中的作用

• 批准号: nhmrc : 1068773
• 负责人: Dr Philip Gregory
• 金额: $ 29.55万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mir-200-cancer-progression/455357
• 关键词: Role; miR; 200; target; Quaking

The spread of cancer to other organs involves cancer cells changing to a more aggressive state and is a major cause of cancer related death. MicroRNAs are a class of genes that control whether cancer cells become more aggressive by regulating other genes. In this project we will examine the function of a new microRNA target which controls the cancer cell aggression. The outcome will be a better understanding of how cancers spread and the identification of new therapeutic targets.

癌症向其他器官的扩散涉及癌细胞转变为更具攻击性的状态，这是癌症相关死亡的主要原因。microrna是一类通过调节其他基因来控制癌细胞是否变得更具攻击性的基因。在这个项目中，我们将研究一个新的microRNA靶点的功能，它控制癌细胞的攻击。其结果将是更好地了解癌症如何扩散和确定新的治疗靶点。