Characterising novel alternative splicing networks that promote tumour cell plasticity

表征促进肿瘤细胞可塑性的新型选择性剪接网络

• 批准号: nhmrc : GNT1128479
• 负责人: Dr Philip Gregory
• 金额: $ 60.93万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-novel-alternative-cell-plasticity/1347695
• 关键词: Characterising; novel; alternative; splicing; networks

During cancer progression, tumour cells can change their properties and become more aggressive and resistant to therapies. We have identified an important regulator of this tumour cell transition, called “Quaking”, which causes widespread changes in gene splicing. We aim to investigate how 'Quaking' causes changes in gene splicing and what the effects of these splicing changes are in tumour cells.

在癌症进展过程中，肿瘤细胞可以改变其特性并变得更具攻击性和对治疗的抵抗力。我们已经确定了这种肿瘤细胞转变的一个重要调节因子，称为“Quaking”，它会引起基因剪接的广泛变化。我们的目标是研究“Quaking”如何引起基因剪接的变化以及这些剪接变化对肿瘤细胞的影响。