The role of NK cell receptors in tumor immunity and cancer therapy

NK细胞受体在肿瘤免疫和癌症治疗中的作用

• 批准号: nhmrc : 1043492
• 负责人: Prof David Ritchie
• 金额: $ 42.76万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nk-cell-cancer-therapy/111581
• 关键词: role; NK; cell; receptors; tumor

White blood cells lymphocytes have an important role to play in cancer immunity and the activity of some cancer therapies. Therapeutics that improve lymphocyte function in patient tumors are showing great promise. Yet, virtually nothing is known about one family of lymphocyte receptors that control function in cancer. Using relevant mouse models of cancer and patient tumors we now wish to assess the relative importance of this family of receptors in tumor immunity, therapy, and escape.

白细胞淋巴细胞在癌症免疫和某些癌症治疗的活性中起着重要作用。改善肿瘤患者淋巴细胞功能的治疗方法显示出巨大的希望。然而，对控制癌症功能的淋巴细胞受体家族几乎一无所知。利用相关的小鼠癌症和患者肿瘤模型，我们现在希望评估这一受体家族在肿瘤免疫、治疗和逃逸中的相对重要性。