Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmission

母胎界面 NK 细胞在妊娠维持和先天性 CMV 传播中的作用

基本信息

  • 批准号:
    10392103
  • 负责人:
  • 金额:
    $ 75.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-07 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

Abstract Immune cells at the maternal/fetal interface play dual roles of orchestrating immune tolerance required for pregnancy maintenance, while also protecting against placental pathogens, such as cytomegalovirus (CMV). Specialized inhibitory immune cells, known as natural killer (NK) cells, are predominant and dynamic immune cells populating the decidua throughout gestation. Yet, there is a major gap in our understanding of the role of NK cells in protection of the fetus against immune rejection and pathogen invasion. The role of NK cells, including recently identified cytomegalovirus (CMV)-specific memory NK cells, in the interplay between fetal tolerance and protection against congenital CMV transmission is poorly defined. This study aims to define the role of maternal NK cell populations in regulation of fetal tolerance and protection against placental CMV transmission in the setting of chronic maternal CMV infection. Our group is uniquely equipped to dissect the immunologic functions at the maternal-fetal interface with significant expertise in both a nonhuman primate (NHP) model of pregnancy and placental CMV transmission as well as investigations of immune cells at the maternal-fetal interface in human placenta and cord blood. The NHP model affords the opportunity to study the immunology and physiology of pregnancy across the gestational stages through elective fetal harvest and access to the immune cells at the maternal-fetal interface, as well as validated strategies for peripheral and tissue depletion of effector NK cells in vivo. We hypothesize that maternal NK cells are critical to both pregnancy maintenance and prevention of CMV reactivation in early pregnancy. Understanding this intersection between maintaining immune tolerance while protecting against placental pathogens is critical to developing immune-based strategies to reduce the morbidity and mortality resulting from adverse pregnancy outcomes.
摘要

项目成果

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Amitinder Kaur其他文献

Amitinder Kaur的其他文献

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{{ truncateString('Amitinder Kaur', 18)}}的其他基金

Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmission
母胎界面 NK 细胞在妊娠维持和先天性 CMV 传播中的作用
  • 批准号:
    10586146
  • 财政年份:
    2022
  • 资助金额:
    $ 75.43万
  • 项目类别:
CMV infection impact on placental immunometabolism and fetal immunity
CMV感染对胎盘免疫代谢及胎儿免疫力的影响
  • 批准号:
    10536197
  • 财政年份:
    2022
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    9022675
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8846538
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8492032
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8660612
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8409973
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
ROLE OF NATURAL KILLER T (NKT) LYMPHOCYTES IN SOOTY MANGABEYS
自然杀伤 T (NKT) 淋巴细胞在乌白眉猴中的作用
  • 批准号:
    8357526
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:
CHARACTERIZATION OF MHC CLASS I ALLELES IN SOOTY MANGABEYS
乌白眉猴 MHC I 类等位基因的特征
  • 批准号:
    8357924
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:
CELLULAR IMMUNE RESPONSES IN SIV-INFECTED SOOTY MANGABEYS
感染 SIV 的乌白眉猴的细胞免疫反应
  • 批准号:
    8357908
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:

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