Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmission

母胎界面 NK 细胞在妊娠维持和先天性 CMV 传播中的作用

基本信息

  • 批准号:
    10392103
  • 负责人:
  • 金额:
    $ 75.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-07 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

Abstract Immune cells at the maternal/fetal interface play dual roles of orchestrating immune tolerance required for pregnancy maintenance, while also protecting against placental pathogens, such as cytomegalovirus (CMV). Specialized inhibitory immune cells, known as natural killer (NK) cells, are predominant and dynamic immune cells populating the decidua throughout gestation. Yet, there is a major gap in our understanding of the role of NK cells in protection of the fetus against immune rejection and pathogen invasion. The role of NK cells, including recently identified cytomegalovirus (CMV)-specific memory NK cells, in the interplay between fetal tolerance and protection against congenital CMV transmission is poorly defined. This study aims to define the role of maternal NK cell populations in regulation of fetal tolerance and protection against placental CMV transmission in the setting of chronic maternal CMV infection. Our group is uniquely equipped to dissect the immunologic functions at the maternal-fetal interface with significant expertise in both a nonhuman primate (NHP) model of pregnancy and placental CMV transmission as well as investigations of immune cells at the maternal-fetal interface in human placenta and cord blood. The NHP model affords the opportunity to study the immunology and physiology of pregnancy across the gestational stages through elective fetal harvest and access to the immune cells at the maternal-fetal interface, as well as validated strategies for peripheral and tissue depletion of effector NK cells in vivo. We hypothesize that maternal NK cells are critical to both pregnancy maintenance and prevention of CMV reactivation in early pregnancy. Understanding this intersection between maintaining immune tolerance while protecting against placental pathogens is critical to developing immune-based strategies to reduce the morbidity and mortality resulting from adverse pregnancy outcomes.
摘要 母体/胎儿界面的免疫细胞发挥着双重作用,协调免疫耐受, 妊娠维持,同时还保护免受胎盘病原体,如巨细胞病毒(CMV)。 专门的抑制性免疫细胞,称为自然杀伤(NK)细胞,是主要的和动态的免疫细胞。 在整个妊娠期间,细胞在蜕膜中繁殖。然而,在我们理解的作用, NK细胞在保护胎儿免受免疫排斥和病原体入侵中的作用。NK细胞的作用, 包括最近发现的巨细胞病毒(CMV)特异性记忆NK细胞,在胎儿 对先天性CMV传播的耐受性和保护性定义不明确。本研究旨在定义 母体NK细胞群在调节胎儿耐受和保护胎盘免受CMV感染中的作用 在慢性母体CMV感染的情况下传播。我们的团队有着独特的能力来解剖 母胎界面的免疫功能,在非人灵长类动物中具有丰富的专业知识 (NHP)妊娠和胎盘CMV传播的模型,以及免疫细胞的调查, 人胎盘和脐带血中的母胎界面。NHP模型提供了研究 通过选择性胎儿收获, 接触母胎界面的免疫细胞,以及外周和 体内效应NK细胞的组织消耗。我们假设母体NK细胞对两者都至关重要 妊娠维持和预防妊娠早期CMV再激活。理解这一 维持免疫耐受与保护免受胎盘病原体侵害之间的交叉点对于 制定以免疫为基础的战略,以减少不良妊娠造成的发病率和死亡率; 结果。

项目成果

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Amitinder Kaur其他文献

Amitinder Kaur的其他文献

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{{ truncateString('Amitinder Kaur', 18)}}的其他基金

Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmission
母胎界面 NK 细胞在妊娠维持和先天性 CMV 传播中的作用
  • 批准号:
    10586146
  • 财政年份:
    2022
  • 资助金额:
    $ 75.43万
  • 项目类别:
CMV infection impact on placental immunometabolism and fetal immunity
CMV感染对胎盘免疫代谢及胎儿免疫力的影响
  • 批准号:
    10536197
  • 财政年份:
    2022
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    9022675
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8846538
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8492032
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8409973
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
NKT cells as modulators of AIDS vaccine efficacy
NKT 细胞作为艾滋病疫苗功效的调节剂
  • 批准号:
    8660612
  • 财政年份:
    2012
  • 资助金额:
    $ 75.43万
  • 项目类别:
ROLE OF NATURAL KILLER T (NKT) LYMPHOCYTES IN SOOTY MANGABEYS
自然杀伤 T (NKT) 淋巴细胞在乌白眉猴中的作用
  • 批准号:
    8357526
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:
CHARACTERIZATION OF MHC CLASS I ALLELES IN SOOTY MANGABEYS
乌白眉猴 MHC I 类等位基因的特征
  • 批准号:
    8357924
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:
CELLULAR IMMUNE RESPONSES IN SIV-INFECTED SOOTY MANGABEYS
感染 SIV 的乌白眉猴的细胞免疫反应
  • 批准号:
    8357908
  • 财政年份:
    2011
  • 资助金额:
    $ 75.43万
  • 项目类别:

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