Immune responses to staphylococcus aureus

对金黄色葡萄球菌的免疫反应

基本信息

  • 批准号:
    3525-2008
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2008
  • 资助国家:
    加拿大
  • 起止时间:
    2008-01-01 至 2009-12-31
  • 项目状态:
    已结题

项目摘要

Staphylococcus aureus is a common bacteria which, in its antibiotic resistant form (MRSA), has become a common and dangerous hospital infection. It also causes mastitis in dairy cattle which is responsible for serious losses to the dairy industry. Unfortunately, most vaccines described up until now are only partially protective and are specific to certain types of infection. This research program which has been underway for several years was designed to study how S. aureus causes changes in the protective responses (immune responses) of infected animals and how these responses alter the efficiency of vaccines. A combination of vaccines made from genetic material (DNA) and proteins of the bacterium has been injected into mice which were then infected with the bacteria. Such DNA/protein vaccines are a relatively new technology that has recently been licensed for some fish viruses and West Nile virus in horses. Our results have suggested that each manifestation of S. aureus infection, be it arthritis, septicemia, endocarditis or mastitis, stimulates a slightly different immune response by the animal. Vaccination against the infection in one part of the body does not necessarily protect against infections at other sites. Thus it is important to identify how the immune responses differ from infection to infection. The immediate objective of this program is to study how the immune responses to S. aureus in mouse models vary during infections at different sites. The longer-term objectives of this program will be to find out how the immune response changes after the animals have been injected with different prototype vaccines. We will continue to use mouse models of S. aureus-induced septicemia, arthritis and mastitis, but we will also use a simulation of the bacterial colonization of the nose. This is often where the bacteria appears to be present in humans but without causing any symptoms. This "nasal carriage" may explain how antibiotic resistant bacteria have spread so fast. The success of such a project will have an important impact in the fight against other emerging and potentially dangerous bacteria.
金黄色葡萄球菌是一种常见细菌,其抗生素耐药性 (MRSA) 已成为一种常见且危险的医院感染。它还会引起奶牛乳腺炎,给乳制品行业造成严重损失。不幸的是,迄今为止描述的大多数疫苗仅具有部分保护作用,并且针对某些类型的感染。这项研究计划已经进行了数年,旨在研究金黄色葡萄球菌如何引起受感染动物的保护性反应(免疫反应)变化以及这些反应如何改变疫苗的效率。 由细菌的遗传物质(DNA)和蛋白质制成的疫苗组合被注射到小鼠体内,然后小鼠被细菌感染。这种 DNA/蛋白质疫苗是一项相对较新的技术,最近已被许可用于某些鱼类病毒和马的西尼罗河病毒。我们的结果表明,金黄色葡萄球菌感染的每种表现,无论是关节炎、败血症、心内膜炎还是乳腺炎,都会刺激动物产生略有不同的免疫反应。针对身体某一部位感染的疫苗不一定能预防其他部位的感染。因此,确定不同感染之间的免疫反应有何不同非常重要。该计划的直接目标是研究小鼠模型中不同部位感染期间对金黄色葡萄球菌的免疫反应如何变化。该计划的长期目标是找出动物注射不同原型疫苗后免疫反应如何变化。我们将继续使用金黄色葡萄球菌引起的败血症、关节炎和乳腺炎的小鼠模型,但我们还将使用鼻子细菌定植的模拟。这通常是细菌似乎存在于人类体内的地方,但不会引起任何症状。 这种“鼻腔运输”可以解释抗生素耐药性细菌为何传播得如此之快。该项目的成功将对对抗其他新兴和潜在危险细菌产生重要影响。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Talbot, Brian其他文献

Product Design and Supply Chain Coordination Under Extended Producer Responsibility
  • DOI:
    10.3401/poms.1080.01018
  • 发表时间:
    2009-05-01
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Subramanian, Ravi;Gupta, Sudheer;Talbot, Brian
  • 通讯作者:
    Talbot, Brian
Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni').
  • DOI:
    10.1002/dta.1668
  • 发表时间:
    2014-07
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Brandt, Simon D.;Baumann, Michael H.;Partilla, John S.;Kavanagh, Pierce V.;Power, John D.;Talbot, Brian;Twamley, Brendan;Mahony, Olivia;O'Brien, John;Elliott, Simon P.;Archer, Roland P.;Patrick, Julian;Singh, Kuldip;Dempster, Nicola M.;Cosbey, Simon H.
  • 通讯作者:
    Cosbey, Simon H.

Talbot, Brian的其他文献

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{{ truncateString('Talbot, Brian', 18)}}的其他基金

Immune responses to staphylococcus aureus
对金黄色葡萄球菌的免疫反应
  • 批准号:
    3525-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
Immune responses to staphylococcus aureus
对金黄色葡萄球菌的免疫反应
  • 批准号:
    3525-2008
  • 财政年份:
    2011
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
Immune responses to staphylococcus aureus
对金黄色葡萄球菌的免疫反应
  • 批准号:
    3525-2008
  • 财政年份:
    2010
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
Immune responses to staphylococcus aureus
对金黄色葡萄球菌的免疫反应
  • 批准号:
    3525-2008
  • 财政年份:
    2009
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
Genetic immunization strategies against bacterial infections. Stratégies d'immunisation génétique contre les infections bactériennes
针对细菌感染的基因免疫策略。
  • 批准号:
    3525-2006
  • 财政年份:
    2006
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
DNA immunization in mouse models of staphylococcus aureus infection
金黄色葡萄球菌感染小鼠模型的 DNA 免疫
  • 批准号:
    3525-2002
  • 财政年份:
    2005
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
DNA immunization in mouse models of staphylococcus aureus infection
金黄色葡萄球菌感染小鼠模型的 DNA 免疫
  • 批准号:
    3525-2002
  • 财政年份:
    2004
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
DNA immunization in mouse models of staphylococcus aureus infection
金黄色葡萄球菌感染小鼠模型的 DNA 免疫
  • 批准号:
    3525-2002
  • 财政年份:
    2003
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
DNA immunization in mouse models of staphylococcus aureus infection
金黄色葡萄球菌感染小鼠模型的 DNA 免疫
  • 批准号:
    3525-2002
  • 财政年份:
    2002
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
Development of DNA-based vaccines for bovine viral diarrhoea virus. Développement des vaccins à base dADN le virus de diarrhée bovine.
开发基于 DNA 的牛病毒性腹泻病毒疫苗。
  • 批准号:
    193189-1996
  • 财政年份:
    1998
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Strategic Projects - Group

相似海外基金

Investigating human immune responses to Staphylococcus aureus skin infection to accelerate vaccine development
研究人体对金黄色葡萄球菌皮肤感染的免疫反应以加速疫苗开发
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  • 批准号:
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Protective versus deleterious immune responses that impact vaccine efficacy against Staphylococcus aureus bloodstream infection
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  • 批准号:
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  • 财政年份:
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  • 资助金额:
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Mechanisms of sensory neuron control over skin immune responses
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  • 项目类别:
Immune responses to staphylococcus aureus
对金黄色葡萄球菌的免疫反应
  • 批准号:
    3525-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Discovery Grants Program - Individual
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人 MAIT 细胞在气道粘膜对细胞内感染的免疫反应中的作用
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Human MAIT celis in airway mucosal immune responses to intracellular infections
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