Role of PAK1 in colorectal cancer growth and metastasis regulated by gastrins

PAK1在胃泌素调节的结直肠癌生长和转移中的作用

• 批准号: nhmrc : 508908
• 负责人: Dr Hong He
• 金额: $ 30.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-pak1-colorectal-regulated-gastrins/94691
• 关键词: Role; PAK1; colorectal; cancer; growth

Increased level of PAK1(a protein kinase) was associated with the progression of colorectal (large bowel) cancer (CRC). Gastrin peptides are growth factors responsible for CRC development. The objective of this project is to determine the role of PAK1 in the regulation of CRC growth and metastasis by gastrin peptides. We will use cell culture, animal models and clinical samples in the program. A successful outcome will lead to the development of new CRC therapies such as inhibitors of PAK1.

PAK1（一种蛋白激酶）水平的升高与结直肠癌（大肠癌）的进展相关。胃泌素肽是负责CRC发展的生长因子。本项目的目的是确定PAK 1在胃泌素肽调节CRC生长和转移中的作用。我们将在项目中使用细胞培养、动物模型和临床样本。成功的结果将导致新的CRC疗法的开发，如PAK1抑制剂。