The role of parasite adhesins in Plasmodium falciparum invasion of human erythrocytes

寄生虫粘附素在恶性疟原虫侵袭人红细胞中的作用

• 批准号: nhmrc : 1026581
• 负责人: Dr Wai-Hong Tham
• 金额: $ 25.7万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-parasite-adhesins-human-erythrocytes/110506
• 关键词: role; parasite; adhesins; Plasmodium; falciparum

Invasion of red blood cells is essential for the survival of malaria parasite within the human host. Red blood cell invasion is mediated by recognition of parasite proteins to specific blood surface receptors. My research focuses on understanding these parasite protein-host receptor interactions with emphasis on translating these findings as novel approaches for the prevention and treatment of malaria.

红细胞的侵入对于疟原虫在人类宿主中的生存至关重要。红细胞侵入是由寄生虫蛋白识别特定的血液表面受体介导的。我的研究重点是了解这些寄生虫蛋白质-宿主受体相互作用，重点是将这些发现转化为预防和治疗疟疾的新方法。