ROLE OF RIP KINASES & IAPs IN MUCOSAL IMMUNE DEFENCE

RIP 激酶的作用

• 批准号: nhmrc : 1057888
• 负责人: Dr Sabrina Mühlen
• 金额: $ 42.09万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-rip-kinases-immune-defence/454642
• 关键词: ROLE; RIP; KINASES; IAPs; MUCOSAL

Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes infection.

致病细菌是炎症信号通路的主要操纵者，旨在阻止它们。了解它们是如何做到这一点的，将使我们能够开发出限制它们感染能力的药物。我们已经证明，致病细菌将一种名为EspL的蛋白质注入人体细胞，以促进一种名为RIP激酶（RIPK）的人类蛋白质家族的破坏，该蛋白质家族协调炎症反应，现在的目标是发现EspL如何导致RIPK降解，从而促进感染。