ROLE OF RIP KINASES & IAPs IN MUCOSAL IMMUNE DEFENCE

病原菌是炎症信号通路的主要操纵者，旨在阻止它们。了解它们是如何做到这一点的，将使我们能够开发出限制它们感染能力的药物。我们已经证明，病原菌将一种名为Espl的蛋白质注入人类细胞，以促进对一族名为RIP激酶(RIPK)的人类蛋白质的破坏，该家族协调炎症反应，现在的目标是发现Espl如何导致RIPK降解，从而促进感染。

Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes infection.