The role of somatic mutations in CCCTC-binding factor (CTCF) binding sites in cancer

CCCTC 结合因子 (CTCF) 结合位点体细胞突变在癌症中的作用

• 批准号: nhmrc : 1119932
• 负责人: A/Pr Jason Wong
• 金额: $ 25.32万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-somatic-mutations-sites-cancer/946393
• 关键词: role; somatic; mutations; CCCTC; binding

The three dimensional organisation of genomic DNA has been recognised to play a crucial role in maintaining the stability and function of human cells. In cancer this organisation is often perturbed as a result of mutations to proteins that govern this process. This project will examine how mutations in the DNA may potentially alter the three dimensional organisation of cancer genomes and will identify links between these mutations with cancer development and patient prognosis.

基因组DNA的三维组织被认为在维持人类细胞的稳定性和功能方面起着至关重要的作用。在癌症中，由于控制这一过程的蛋白质发生突变，这种组织经常受到干扰。该项目将研究DNA突变如何潜在地改变癌症基因组的三维组织，并将确定这些突变与癌症发展和患者预后之间的联系。