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Investigating the Molecular Basis for Drug Resistance and Disease Relapse in Myelodysplastic Syndromes

Investigating the Molecular Basis for Drug Resistance and Disease Relapse in Myelodysplastic Syndromes
研究骨髓增生异常综合征耐药性和疾病复发的分子基础
批准号:
nhmrc : GNT1139787
负责人:
A/Pr Jason Wong
金额:
$72.26万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
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英文摘要
Myelodysplastic Syndromes (MDS) are a group of blood stem cell disorders that result in low blood counts and leukemia especially in the elderly. Azacitidine (AZA) is a drug that improves blood counts and delays progression to leukemia and is the treatment of choice. However, only half the patients treated with AZA ever respond and half of the responders relapse within a year. We will describe the origins of MDS and the basis for drug response, resistance and disease relapse.
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