Reconstructing Transcriptional Networks in Leukaemic Cells

重建白血病细胞的转录网络

• 批准号: nhmrc : 1042934
• 负责人: A/Pr Jason Wong
• 金额: $ 50.68万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reconstructing-transcriptional-networks-leukaemic-cells/111528
• 关键词: Reconstructing; Transcriptional; Networks; Leukaemic; Cells

Cancer stem cells adopt properties of normal stem cells to survive and proliferate in the body. If we are to eradicate cancer stem cells without eradicating normal stem cells, it is of fundamental importance to recognize and target biological differences that exist between these cells. Our aim is to first understand how ‘stemness’ is maintained in normal and leukaemic cells with the ultimate objective of dismantling ‘stemness’ in the latter whilst preserving it in the former.

癌症干细胞采用正常干细胞的特性在体内存活和增殖。如果我们要在不根除正常干细胞的情况下根除癌症干细胞，认识到并针对这些细胞之间存在的生物学差异是至关重要的。我们的目标是首先了解在正常细胞和白血病细胞中是如何保持“干性”的，最终目标是在前者中保留“干性”的同时消除后者中的“干性”。