Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes

鞘脂信号传导在肝脏胰岛素抵抗中的作用及其在预测 2 型糖尿病和糖尿病前期风险中的应用

• 批准号: nhmrc : 1113527
• 负责人: Prof Geoffrey Mccaughan
• 金额: $ 38.83万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sphingolipid-signalling-diabetes-prediabetes/663256
• 关键词: Role; sphingolipid; signalling; hepatic; insulin

Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target

2型糖尿病预计将在未来几十年达到流行病的比例。前驱糖尿病通常未被识别，并且构成需要早期干预的主要公共卫生问题，因为大多数前驱糖尿病受试者进展为T2D。我们已经确定了一种在胰岛素信号传导中起重要作用的酶。这种酶的水平或活性可能是糖尿病前期状态的潜在生物标志物，也可以用作靶点。