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Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes

Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes
鞘脂信号传导在肝脏胰岛素抵抗中的作用及其在预测 2 型糖尿病和糖尿病前期风险中的应用
批准号:
nhmrc : 1113527
负责人:
Prof Geoffrey Mccaughan
金额:
$38.83万
依托单位国家:
澳大利亚
项目类别:
Targeted Calls
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2020-12-31

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中文摘要
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英文摘要
Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target
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会议论文
Hepatocellular Carcinoma: understanding the genotoxic risks of liver-targeted gene therapy using recombinant AAV vectors
  • 批准号:
    nhmrc : 1145116
  • 项目类别:
    Project Grants
  • 资助金额:
    $60.29万
  • 财政年份:
    2018
  • 负责人:
    Prof Geoffrey Mccaughan
  • 依托单位:
A novel liver cancer therapy targeting tumour stroma
  • 批准号:
    nhmrc : 1113842
  • 项目类别:
    Development Grants
  • 资助金额:
    $26.42万
  • 财政年份:
    2016
  • 负责人:
    Prof Geoffrey Mccaughan
  • 依托单位:
DPP4 family proteases as drivers of chronic liver injury
  • 批准号:
    nhmrc : 1105238
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.15万
  • 财政年份:
    2016
  • 负责人:
    Prof Geoffrey Mccaughan
  • 依托单位:
Roles of enzymes of the dipeptidyl peptidase gene family in human liver
  • 批准号:
    nhmrc : 293803
  • 项目类别:
    NHMRC Strategic Awards
  • 资助金额:
    $5.32万
  • 财政年份:
    2005
  • 负责人:
    Prof Geoffrey Mccaughan
  • 依托单位:
海外基金