DPP4 family proteases as drivers of chronic liver injury

DPP4 家族蛋白酶是慢性肝损伤的驱动因素

• 批准号: nhmrc : 1105238
• 负责人: Prof Geoffrey Mccaughan
• 金额: $ 50.15万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dpp4-family-proteases-liver-injury/662811
• 关键词: DPP4; family; proteases; drivers; chronic

Type 2 diabetes afflicts over 220 million people and often causes a chronic liver injury. That and hepatitis viruses can cause cirrhosis, liver failure and liver cancer, which is the 2nd most common cause of cancer death. Many Australians suffer from diabetes, fatty liver and/or hepatitis virus infection. We will understand these diseases far better and likely discover a new therapy by assessing roles of the DPP4 family of enzymes in diabetes, fibrosis and fatty liver.

2型糖尿病困扰着超过2.2亿人，通常会导致慢性肝损伤。这和肝炎病毒可以导致肝硬化，肝衰竭和肝癌，这是第二个最常见的癌症死亡原因。许多澳大利亚人患有糖尿病、脂肪肝和/或肝炎病毒感染。我们将更好地了解这些疾病，并可能通过评估DPP 4家族酶在糖尿病，纤维化和脂肪肝中的作用来发现新的治疗方法。