Role of SPPL2A on B cell survival and antibody production in mice and humans

SPPL2A 对小鼠和人类 B 细胞存活和抗体产生的作用

• 批准号: nhmrc : GNT1084237
• 负责人: A/Pr Anselm Enders
• 金额: $ 56.99万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sppl2a-b-mice-humans/1345546
• 关键词: Role; SPPL2A; cell; survival; antibody

B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.

B淋巴细胞是一种特殊类型的血细胞，可产生抗体以应对病原体或疫苗。我们最近发现，所有成熟的B细胞的生存依赖于一种以前未知的蛋白SPPL 2A。本申请将研究SPPL 2A促进B细胞存活的分子机制。我们还将研究目前无法解释的B细胞缺乏症患者是否存在SPPL 2A突变。