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Role of SPPL2A on B cell survival and antibody production in mice and humans

Role of SPPL2A on B cell survival and antibody production in mice and humans
SPPL2A 对小鼠和人类 B 细胞存活和抗体产生的作用
批准号:
nhmrc : GNT1084237
负责人:
A/Pr Anselm Enders
金额:
$56.99万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 --

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中文摘要
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英文摘要
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
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