Cholestasis and hepatocyte injury in chronic liver disease

慢性肝病中的胆汁淤积和肝细胞损伤

• 批准号: nhmrc : GNT1120898
• 负责人: A/Pr Anselm Enders
• 金额: $ 61.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cholestasis-hepatocyte-injury-liver-disease/1347171
• 关键词: Cholestasis; hepatocyte; injury; chronic; liver

The aim of this project is to understand the consequences of long-term cholestasis or impaired bile excretion/flow on normal liver cells (hepatocytes) and to test whether specific bile acids can cause irreversible damage to hepatocytes leading to their transformation into pre-malignant cells and hepatocellular carcinoma (primary liver cancer). The results from this project will inform new strategies in screening, prevention and treatment of liver cancer in children and adults with cholestasis.

该项目的目的是了解长期胆汁淤积或胆汁排泄/流动受损对正常肝细胞（肝细胞）的影响，并测试特定胆汁酸是否会对肝细胞造成不可逆损伤，导致其转化为恶性前细胞和肝细胞癌（原发性肝癌）。该项目的结果将为儿童和成人胆汁淤积症肝癌的筛查、预防和治疗提供新的策略。