Role of survival motor neuron deficiency in motor neuron disease

运动神经元存活缺陷在运动神经元疾病中的作用

• 批准号: nhmrc : 1008910
• 负责人: Dr Bradley Turner
• 金额: $ 35.46万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-survival-motor-neuron-disease/109355
• 关键词: Role; survival; motor; neuron; deficiency

The aim of this proposal is to understand the earliest and central pathological events in motor neuron disease (MND). This is important for drug development because therapies that target the early disease stages are likely to be effective. Our previous studies suggest that a protein essential for nerve cells, survival motor neuron, is lacking in MND. We will therefore examine how early this deficiency starts in disease and whether its replacement is beneficial. These outcomes may aid future studies to design new treatments for MND.

该提案的目的是了解运动神经元疾病 (MND) 中最早和最核心的病理事件。这对于药物开发很重要，因为针对疾病早期阶段的疗法可能是有效的。我们之前的研究表明，MND 中缺乏神经细胞（运动神经元存活）所必需的蛋白质。因此，我们将检查这种缺陷在疾病中多久开始，以及替代它是否有益。这些结果可能有助于未来的研究设计新的 MND 治疗方法。