Astrocytes, mutant TDP-43 and non-cell autonomous injury of motoneurons

星形胶质细胞、TDP-43突变和运动神经元的非细胞自主损伤

• 批准号: nhmrc : 1023780
• 负责人: Dr Bradley Turner
• 金额: $ 41.77万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/astrocytes-mutant-tdp-injury-motoneurons/110301
• 关键词: Astrocytes; mutant; TDP; 43; non

Motor neuron disease (MND) leads to death of nerve cells, paralysis and death. There is no cure. Mutations in the protein TDP43 cause MND. In this study we will investigate the underlying mechanisms of which these mutations cause disease. We will also investigate how these mutations affect astrocytes, a cell type that maintains normal function and survival of nerve cells and determine if the mutations affect the important interactions that normally takes place between these cell types.

运动神经元病(MND)可导致神经细胞死亡、瘫痪和死亡。没有治愈的方法。蛋白质TDP43的突变会导致MND。在这项研究中，我们将研究这些突变导致疾病的潜在机制。我们还将研究这些突变如何影响星形胶质细胞，星形胶质细胞是一种维持神经细胞正常功能和存活的细胞类型，并确定这些突变是否影响这些细胞类型之间正常发生的重要相互作用。