Targeting autophagy to improve protein metabolism in ALS

靶向自噬改善 ALS 中的蛋白质代谢

• 批准号: nhmrc : 1104295
• 负责人: Dr Bradley Turner
• 金额: $ 40.19万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-autophagy-improve-metabolism-als/662740
• 关键词: Targeting; autophagy; improve; protein; metabolism

One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent drug which enhances autophagy, a protective process which breaks down protein deposits inside cells. We have shown that this autophagy enhancer efficiently clears protein deposits linked to MND in the Petri dish. We propose to treat MND mice with this autophagy enhancer and predict that it will slow disease signs, preserve lifespan and protect nerve cells.

MND的一个共同特征是在神经细胞内积累蛋白质沉积，导致神经细胞死亡。我们已经确定了一种有效的药物，可以增强自噬，自噬是一种保护过程，可以分解细胞内的蛋白质沉积。我们已经证明，这种自噬增强剂有效地清除了培养皿中与MND有关的蛋白质沉积。我们建议用这种自噬增强剂治疗MND小鼠，并预测它将减缓疾病症状，延长寿命并保护神经细胞。