The role of the TGF-b superfamily cytokine MIC-1 in prostate cancer pathogenesis

TGF-b超家族细胞因子MIC-1在前列腺癌发病机制中的作用

• 批准号: nhmrc : 568762
• 负责人: Prof Samuel Breit
• 金额: $ 38.62万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tgf-b-cancer-pathogenesis/100459
• 关键词: role; TGF; superfamily; cytokine; MIC

We have discovered that a protein called MIC-1 is strongly linked to prostate cancer and is made in large amounts by this tumor. There is a lot of circumstantial evidence that it is involved in the prostate cancer but the proof is missing. We propose to breed mice that are both prostate cancer prone and have genetically modified MIC-1 : mice either are unable to make MIC-1 , or make it in large amounts. We will determine how MIC-1 affects prostate cancer development.

我们发现，一种名为MIC-1的蛋白质与前列腺癌密切相关，并由前列腺癌大量产生。有很多间接证据表明它与前列腺癌有关，但缺乏证据。我们建议培育既易患前列腺癌又具有转基因MIC-1的小鼠：小鼠要么无法制造MIC-1，要么大量制造MIC-1。我们将确定MIC-1如何影响前列腺癌的发展。