The role of the TGF-b superfamily cytokine MIC-1 in the pathogenesis of atherosclerosis

TGF-b超家族细胞因子MIC-1在动脉粥样硬化发病机制中的作用

• 批准号: nhmrc : 300501
• 负责人: Prof Samuel Breit
• 金额: $ 23.27万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tgf-b-pathogenesis-atherosclerosis/82224
• 关键词: role; TGF; superfamily; cytokine; MIC

MIC-1 is a protein first cloned and characterised by our research group. It belongs to the TGF beta protein superfamily which is very important in development, cancer, wound - fracture healing and inflammation. The aim of this project was to start to gain an understanding of the role of this protein, both in normal biological processes (especially pregnancy) and in disease. MIC-1 is present in the blood of all individuals and high levels are associated with an increased risk of heart attacks and strokes. In this study we wish to use animal models, in which the gene for MIC-1 has either been deleted or enhanced, to determine whether MIIC-1 plays a direct role in these diseases.

MIC-1是我们研究小组首次克隆和鉴定的蛋白质。它属于TGF β蛋白超家族，其在发育、癌症、创伤-骨折愈合和炎症中非常重要。该项目的目的是开始了解这种蛋白质在正常生物过程（特别是怀孕）和疾病中的作用。MIC-1存在于所有个体的血液中，高水平与心脏病发作和中风的风险增加有关。在这项研究中，我们希望使用动物模型，其中MIC-1基因已经删除或增强，以确定MIIC-1是否在这些疾病中发挥直接作用。